Multisite phosphorylation of 14-3-3 proteins by calcium-dependent protein kinases
نویسندگان
چکیده
منابع مشابه
Multisite phosphorylation of 14-3-3 proteins by calcium-dependent protein kinases.
Plant 14-3-3 proteins are phosphorylated at multiple sites in vivo; however, the protein kinase(s) responsible are unknown. Of the 34 CPK (calcium-dependent protein kinase) paralogues in Arabidopsis thaliana, three (CPK1, CPK24 and CPK28) contain a canonical 14-3-3-binding motif. These three, in addition to CPK3, CPK6 and CPK8, were tested for activity against recombinant 14-3-3 proteins χ and ...
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The 14-3-3 proteins are important effectors of Ser/Thr phosphorylation in eukaryotic cells. Using mathematical modelling we investigated the roles of these proteins as effectors in signalling pathways that involve multi-phosphorylation events. We defined optimal conditions for positive and negative cross-talk. Particularly, synergistic signal interaction was evident at very different sets of bi...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2014
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj20130035